BRCA1 and BRCA2
Click here for the source page from cancer.gov
FEMALES
BRCA1
[ CUP
C akes]
mutations
may increase risk of
cervical
uterine
pancreatic
colon
cancer
BRCA2
[ PaSt GaMe
]
mutations
may increase the risk of
MALES
BRCA1
[Breast [Pan ProTest]
associated
with
possibly
associate with following cancers as well
pancreatic
prostate
[early onset]
testicular
BRCA2
[Pan ProBer]
The
following are more strongly associated with BRCA2
than BRCA1
mutations
pancreatic
prostate
breast
TESTING
Currently, there are no standard
criteria for recommending BRCA1
or BRCA2 mutation
testing.
In a family with a history of breast
and/or ovarian cancer, it may be most informative to first test a
family member who has breast or ovarian cancer.
If that person is found to have a
harmful BRCA1 or
BRCA2 mutation, then
other family members
can be tested to see if they also have the
mutation.
HNPCC
(hereditary non-polyposis colorectal cancer)
Click here for the source page from mcmillan.org
rare
most
common hereditary bowel cancer
<
5% of bowel cancers linked to HNPCC
Women
with HNPCC at increased risk of endometrial cancer
fault
in 'mismatch repair' gene
Suspect in
families with following cancers over several generations
Specifically, suspect if:
≥ 2
relatives on the same side of family had bowel cancer
family
member had bowel cancer under 45
cases
of bowel and uterine cancer on same side of family
≥ 3
relatives on the same side of family have had one HNPCC-type
cancer
[not necessarily the same kind]
Genetic testing
All that's
needed is a blood sample, but it can take a while (up to a year) to
get results
as the genes are large and the faulty gene may be
difficult to find.